A systematic evaluation of Schwann cell injection into acellular cold-preserved nerve grafts.

@article{Jesuraj2011ASE,
  title={A systematic evaluation of Schwann cell injection into acellular cold-preserved nerve grafts.},
  author={Nithya J Jesuraj and Katherine B Santosa and Piyaraj Newton and Zhong-lin Liu and Daniel A. Hunter and Susan E. Mackinnon and Shelly E Sakiyama-Elbert and Philip James Johnson},
  journal={Journal of neuroscience methods},
  year={2011},
  volume={197 2},
  pages={209-15}
}
Peripheral nerve regeneration after injury depends on environmental cues and trophic support. Schwann cells (SCs) secrete trophic factors that promote neuronal survival and help guide axons during regeneration. The addition of SCs to acellular nerve grafts is a promising strategy for enhancing peripheral nerve regeneration; however, inconsistencies in seeding parameters have led to varying results. The current work sought to establish a systematic approach to seeding SCs in cold-preserved… CONTINUE READING