A systematic atlas of chaperome deregulation topologies across the human cancer landscape

Abstract

Proteome balance is safeguarded by the proteostasis network (PN), an intricately regulated network of conserved processes that evolved to maintain native function of the diverse ensemble of protein species, ensuring cellular and organismal health. Proteostasis imbalances and collapse are implicated in a spectrum of human diseases, from neurodegeneration to… (More)
DOI: 10.1371/journal.pcbi.1005890

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