A systematic assessment of common genetic variation in CYP11A and risk of breast cancer.

@article{Setiawan2006ASA,
  title={A systematic assessment of common genetic variation in CYP11A and risk of breast cancer.},
  author={Veronica Wendy Setiawan and I. J. Cheng and Daniel O. Stram and Elena E. Giorgi and Malcolm C. Pike and David J. Van Den Berg and Loreall C. Pooler and No{\"e}l P. Burtt and Lo{\"i}c Le Marchand and David Altshuler and Joel Hirschhorn and Brian E. Henderson and Christopher A. Haiman},
  journal={Cancer research},
  year={2006},
  volume={66 24},
  pages={12019-25}
}
CYP11A catalyzes the rate-limiting step in the biosynthesis of sex-steroid hormones. In this study, we employed a systematic approach that involved gene resequencing and a haplotype-based analysis to investigate the relationship between common variation in CYP11A and breast cancer risk among African-Americans, Latinas, Japanese-Americans, Native Hawaiians, and Whites in the Multiethnic Cohort Study. Resequencing in a multiethnic panel of 95 advanced breast cancer cases revealed no common… CONTINUE READING

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