A systematic analysis of intrinsic regulators for HIV-1 R5 to X4 phenotypic switch

@article{Yu2017ASA,
  title={A systematic analysis of intrinsic regulators for HIV-1 R5 to X4 phenotypic switch},
  author={Wei Yu and Yu Wu},
  journal={Quantitative Biology},
  year={2017},
  volume={5},
  pages={173-182}
}
Human immunodeficiency virus isolates most often use chemokine receptor CCR5 or CXCR4 as a co-receptor to enter target cells. During early stages of HIV-1 infection, CCR5-tropic viruses are the predominant species. The CXCR4-tropic viruses may emerge late in infection. Recognition of factors influencing this phenotypic switch may give some hints on the antiviral strategies like anti-HIV/AIDS drugs, gene therapy and vaccines. To investigate the mechanism that triggers R5 to X4 phenotypic switch… CONTINUE READING