A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly

@article{Krastev2011ASR,
  title={A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly},
  author={Dragomir B. Krastev and Mikolaj Slabicki and Maciej Paszkowski-Rogacz and Nina C. Hubner and Magno Junqueira and Andrej Shevchenko and Matthias Mann and Karla M Neugebauer and Frank Buchholz},
  journal={Nature Cell Biology},
  year={2011},
  volume={13},
  pages={809-818}
}
TP53(tumour protein 53) is one of the most frequently mutated genes in human cancer and its role during cellular transformation has been studied extensively. However, the homeostatic functions of p53 are less well understood. Here, we explore the molecular dependency network of TP53 through an RNAi-mediated synthetic interaction screen employing two HCT116 isogenic cell lines and a genome-scale endoribonuclease-prepared short interfering RNA library. We identify a variety of TP53 synthetic… CONTINUE READING
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