A system for the propagation of adenoviral vectors with genetically modified receptor specificities

@article{Douglas1999ASF,
  title={A system for the propagation of adenoviral vectors with genetically modified receptor specificities},
  author={Joanne T. Douglas and C Ryan Miller and Myunghee Kim and Igor Dmitriev and Galina Mikheeva and Victor N. Krasnykh and David T. Curiel},
  journal={Nature Biotechnology},
  year={1999},
  volume={17},
  pages={470-475}
}
The development of genetically modified adenovirus (Ad) vectors with specificity for a single cell type will require both the introduction of novel tropism determinants and the ablation of endogenous tropism. Consequently, it will not be possible to exploit the native cellular entry pathway in the propagation of these targeted Ad vectors. Based on the concept that Ad enters cells by a two-step process in which a primary receptor serves as a high affinity binding site for the Ad fiber knob, with… CONTINUE READING
39 Citations
40 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Characterization of an adenoviral vector containing a heterologous peptide epitope in the HIloop of the fiber knob

  • V. N. Krasnykh
  • J . Virol .
  • 1998

Enhanced in vivo gene delivery to human ovarian cancer xenografts utilizing a tropismmodified adenovirus vector

  • B. E. Rogers
  • Tumor Targeting
  • 1998

Targeting adenoviral infection with basic fibroblast growth factor enhances gene delivery to vascular endothelial and smooth muscle cells

  • P. N. Reynolds
  • Tumor Targeting
  • 1998

Similar Papers

Loading similar papers…