A synthetic trivalent hapten that aggregates anti-2,4-DNP IgG into bicyclic trimers.

@article{Bilgier2007AST,
  title={A synthetic trivalent hapten that aggregates anti-2,4-DNP IgG into bicyclic trimers.},
  author={Başar Bilgiçer and Demetri Theodore Moustakas and George M Whitesides},
  journal={Journal of the American Chemical Society},
  year={2007},
  volume={129 12},
  pages={3722-8}
}
This paper describes the synthesis of the trivalent hapten molecule 1, containing three 2,4-dinitrophenyl (2,4-DNP) groups, and the use of this molecule to aggregate three molecules of anti-2,4-DNP IgG into a complex with 3:2 stoichiometry (IgG312). The equilibrium product IgG312 was generated in approximately 90% yield upon mixing IgG and 1; during incubation, thermodynamically unstable, high-molecular-weight aggregates (>104 nm in diameter) form first and convert subsequently to IgG312. The… CONTINUE READING