A synthetic route to the saxitoxin skeleton: synthesis of decarbamoyl α-saxitoxinol, an analogue of saxitoxin produced by the cyanobacterium Lyngbya wollei.

@article{Sawayama2011ASR,
  title={A synthetic route to the saxitoxin skeleton: synthesis of decarbamoyl $\alpha$-saxitoxinol, an analogue of saxitoxin produced by the cyanobacterium Lyngbya wollei.},
  author={Yusuke Sawayama and Toshio Nishikawa},
  journal={Angewandte Chemie},
  year={2011},
  volume={50 31},
  pages={
          7176-8
        }
}
Saxitoxin (1), which was first isolated as a paralytic shellfish poison, is a potent and specific blocker of voltage-gated sodium channels, similar to tetrodotoxin, the puffer fish toxin. This unique biological activity prompted us to use saxitoxin and tetrodotoxin as biochemical tools for the study of voltage-gated sodium channels and other ion channels in the field of neurophysiology. Recently, molecular genetic analyses have revealed that ten subtypes of voltage-gated sodium channels are… 
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