A synthetic prestin reveals protein domains and molecular operation of outer hair cell piezoelectricity.

@article{Schaechinger2011ASP,
  title={A synthetic prestin reveals protein domains and molecular operation of outer hair cell piezoelectricity.},
  author={Thorsten J. Schaechinger and Dmitry S. Gorbunov and Christian R. Halaszovich and Tobias Moser and Sebastian K{\"u}gler and Bernd Fakler and Dominik Oliver},
  journal={The EMBO journal},
  year={2011},
  volume={30 14},
  pages={2793-804}
}
Prestin, a transporter-like protein of the SLC26A family, acts as a piezoelectric transducer that mediates the fast electromotility of outer hair cells required for cochlear amplification and auditory acuity in mammals. Non-mammalian prestin orthologues are anion transporters without piezoelectric activity. Here, we generated synthetic prestin (SynPres), a chimera of mammalian and non-mammalian prestin exhibiting both, piezoelectric properties and anion transport. SynPres delineates two… CONTINUE READING

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