A synthetic peptide vector system for optimal gene delivery to corneal endothelium.

@article{Collins2004ASP,
  title={A synthetic peptide vector system for optimal gene delivery to corneal endothelium.},
  author={Louise E Collins and John Fabre},
  journal={The journal of gene medicine},
  year={2004},
  volume={6 2},
  pages={185-94}
}
BACKGROUND Efficient and non-toxic gene delivery, preferably with non-viral DNA vectors readily transferable to clinical practice, is generally regarded as a major limitation for gene therapy. METHODS A 31 amino acid, integrin-targeted bifunctional synthetic peptide (polylysine-molossin), and two (Lys)(16)-containing control peptides, were assessed for ex vivo gene delivery to the rabbit cornea. Critical physical properties of polylysine-molossin/DNA complexes were evaluated and both… CONTINUE READING

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