A synthetic peptide from transforming growth factor-β₁ type III receptor inhibits NADPH oxidase and prevents oxidative stress in the kidney of spontaneously hypertensive rats.

@article{Baltans2013ASP,
  title={A synthetic peptide from transforming growth factor-β₁ type III receptor inhibits NADPH oxidase and prevents oxidative stress in the kidney of spontaneously hypertensive rats.},
  author={Ana Baltan{\'a}s and Jos{\'e} Luis Miguel-Carrasco and Gorka San Jos{\'e} and Carolina Cebri{\'a}n and Maria de Ujue Moreno and Javier Dotor and Francisco Borr{\'a}s-Cuesta and Bego{\~n}a Soler L{\'o}pez and Arantxa Gonz{\'a}lez and J M Olivares D{\'i}ez and Ana Fortu{\~n}o and Guillermo Zalba},
  journal={Antioxidants & redox signaling},
  year={2013},
  volume={19 14},
  pages={1607-18}
}
AIMS The NADPH oxidases constitute a major source of superoxide anion (·O2(-)) in hypertension. Several studies suggest an important role of NADPH oxidases in different effects mediated by transforming growth factor-β₁ (TGF-β₁). We investigated whether a chronic treatment with P144, a peptide synthesized from type III TGF-β₁ receptor, inhibited NADPH oxidases in the renal cortex of spontaneously hypertensive rats (SHR). RESULTS Here, we show that chronic administration of P144 significantly… CONTINUE READING
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