A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury.

@article{Ezquerro2003ASP,
  title={A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury.},
  author={Ignacio-Jos{\'e} Ezquerro and Juan J Lasarte and Javier Dotor and Inma Castilla-Cortazar and Ma.Emilia Bustos and Iv{\'a}n Pe{\~n}uelas and Gemma Huguet i Blanco and C. Osvaldo Rodriguez and Maria del Carmen G Lechuga and Patricia Greenwel and Marcos Rojkind and Jes{\'u}s Prieto and Francisco Borr{\'a}s-Cuesta},
  journal={Cytokine},
  year={2003},
  volume={22 1-2},
  pages={
          12-20
        }
}
Transforming growth factor beta1 (TGF-beta1) is a pleiotropic cytokine, which displays potent profibrogenic effects and is highly expressed in fibrotic livers. For this reason, development of TGF-B1 inhibitors might be of great importance to control liver fibrogenesis as well as other undesired side effects due to this cytokine. Potential peptide inhibitors of TGF-beta1 (derived from TGF-beta1 and from its type III receptor) were tested in vitro and in vivo using different assays. Peptides P11… CONTINUE READING
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