A synthetic peptide from myelin proteolipid protein induces experimental allergic encephalomyelitis.

@article{Tuohy1988ASP,
  title={A synthetic peptide from myelin proteolipid protein induces experimental allergic encephalomyelitis.},
  author={Vincent K. Tuohy and Zichun J Lu and Raymond A Sobel and Richard A. Laursen and Marjorie B. Lees},
  journal={Journal of immunology},
  year={1988},
  volume={141 4},
  pages={1126-30}
}
Immunization of animals with proteolipid protein, the major protein constituent of central nervous system myelin, produces experimental allergic encephalomyelitis. The goal of the present study was to identify an encephalitogenic determinant of this protein. For this purpose, SWR mice were immunized with five groups of pooled synthetic peptides corresponding to various regions of the myelin proteolipid protein sequence. Clinical EAE was observed in only one group. Inguinal lymph node cells from… CONTINUE READING

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