A synthetic peptide containing the IKVAV sequence from the A chain of laminin mediates cell attachment, migration, and neurite outgrowth.

@article{Tashiro1989ASP,
  title={A synthetic peptide containing the IKVAV sequence from the A chain of laminin mediates cell attachment, migration, and neurite outgrowth.},
  author={K. Tashiro and G. Sephel and B. Weeks and M. Sasaki and G. Martin and H. Kleinman and Y. Yamada},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 27},
  pages={
          16174-82
        }
}
Laminin is a basement membrane glycoprotein which consists of A, B1, and B2 chains. [...] Key Result A 19-mer peptide (designated PA22-2), from just above the carboxyl globule on the long arm of the A chain, was found to promote cell adhesion, spreading, migration, and neurite outgrowth. By testing smaller sequences within the 19-mer peptide, a constituent pentapeptide, IKVAV (Ile-Lys-Val-Ala-Val), was identified as the active site for cell adhesion and neurite outgrowth.Expand
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