A synthetic oscillatory network of transcriptional regulators

@article{Elowitz2000ASO,
  title={A synthetic oscillatory network of transcriptional regulators},
  author={M. Elowitz and S. Leibler},
  journal={Nature},
  year={2000},
  volume={403},
  pages={335-338}
}
Networks of interacting biomolecules carry out many essential functions in living cells, but the ‘design principles’ underlying the functioning of such intracellular networks remain poorly understood, despite intensive efforts including quantitative analysis of relatively simple systems. Here we present a complementary approach to this problem: the design and construction of a synthetic network to implement a particular function. We used three transcriptional repressor systems that are not part… Expand
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