A synthetic oligopeptide derived from enamel matrix derivative promotes the differentiation of human periodontal ligament stem cells into osteoblast-like cells with increased mineralization.

@article{Kato2013ASO,
  title={A synthetic oligopeptide derived from enamel matrix derivative promotes the differentiation of human periodontal ligament stem cells into osteoblast-like cells with increased mineralization.},
  author={Hirohito Kato and Nobuhito Katayama and Yoichiro Taguchi and Kazuya Tominaga and Makoto Umeda and Akio Tanaka},
  journal={Journal of periodontology},
  year={2013},
  volume={84 10},
  pages={1476-83}
}
BACKGROUND In a previous study, the authors obtained a synthetic peptide (SP) for useful periodontal tissue regeneration. Periodontal ligament stem cells (PDLSCs) have multiple potentiality to contribute to tissue regeneration. The aim of this experiment is to investigate the effect of SP on human PDLSCs. METHODS Periodontal ligament cells were obtained from healthy adult human third molars and used to isolate single PDLSC-derived colonies. The mesenchymal stem cell nature of the PDLSCs was… CONTINUE READING

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