A synthetic method suitable for the rapid preparation of 13N-labeled dermorphin analogue, H-Tyr-D-Met(O)-Phe-Gly-NH2 (SD-62).

Abstract

A synthetic method suitable for the preparation of 13N-labeled dermorphin analogue, H-Tyr-D-Met(O)-Phe-Gly-NH2 (SD-62), was established; i.e., SD-62 was synthesized by a 5 min treatment of the active ester precursor with ammonia. When the 13N-labeled SD-62, prepared by this method with [13N]ammonia, was administered into mice, the time profile of the radioactivity accumulation in the brain paralleled well that of the analgesic activity.

Cite this paper

@article{Kiso1991ASM, title={A synthetic method suitable for the rapid preparation of 13N-labeled dermorphin analogue, H-Tyr-D-Met(O)-Phe-Gly-NH2 (SD-62).}, author={Yasuo Kiso and Shigemi Iinuma and Tomoaki Mimoto and Hideo Saji and Akira Yokoyama and Kenichi Akaji}, journal={Chemical & pharmaceutical bulletin}, year={1991}, volume={39 10}, pages={2734-6} }