A synthetic mammalian gene circuit reveals antituberculosis compounds

@article{Weber2008ASM,
  title={A synthetic mammalian gene circuit reveals antituberculosis compounds},
  author={W. Weber and R. Schoenmakers and B. Keller and M. Gitzinger and Thomas Grau and M. Daoud-El Baba and P. Sander and M. Fussenegger},
  journal={Proceedings of the National Academy of Sciences},
  year={2008},
  volume={105},
  pages={9994 - 9998}
}
Synthetic biology provides insight into natural gene-network dynamics and enables assembly of engineered transcription circuitries for production of difficult-to-access therapeutic molecules. In Mycobacterium tuberculosis EthR binds to a specific operator (OethR) thereby repressing ethA and preventing EthA-catalyzed conversion of the prodrug ethionamide, which increases the resistance of the pathogen to this last-line-of-defense treatment. We have designed a synthetic mammalian gene circuit… Expand
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