A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis

@inproceedings{Kranz2014ASL,
  title={A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis},
  author={Dominique Kranz and Michael Boutros},
  booktitle={The EMBO journal},
  year={2014}
}
The extrinsic apoptosis pathway is initiated by binding of death ligands to death receptors resulting in the formation of the death-inducing signaling complex (DISC). Activation of procaspase-8 within the DISC and its release from the signaling complex is required for processing executor caspases and commiting cell death. Here, we report that the atypical cadherin FAT1 interacts with caspase-8 preventing the association of caspase-8 with the DISC. We identified FAT1 in a genome-wide siRNA… CONTINUE READING
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It's not over until the FAT lady sings.

The EMBO journal • 2014
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