A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.

@article{Culmsee2001ASI,
  title={A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.},
  author={Carsten Culmsee and Xiongwei Zhu and Qing Yu and Sic Lung Chan and Simonetta Camandola and Zhiwei Guo and Nigel H. Greig and Mark P. Mattson},
  journal={Journal of neurochemistry},
  year={2001},
  volume={77 1},
  pages={
          220-8
        }
}
The tumor suppressor protein p53 is essential for neuronal death in several experimental settings and may participate in human neurodegenerative disorders. Based upon recent studies characterizing chemical inhibitors of p53 in preclinical studies in the cancer therapy field, we synthesized the compound pifithrin-alpha and evaluated its potential neuroprotective properties in experimental models relevant to the pathogenesis of stroke and neurodegenerative disorders. Pifithrin-alpha protected… CONTINUE READING
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