A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia.

@article{Evans2009ASF,
  title={A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia.},
  author={Mark J. Evans and Paige E. Mahaney and Lisa A Borges-Marcucci and Kehdih Lai and Shuguang Wang and Julie A Krueger and Stephen J. Gardell and Christine Huard and Robert V. Martinez and George P. Vlasuk and Douglas C. Harnish},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2009},
  volume={296 3},
  pages={G543-52}
}
The nuclear hormone receptor farnesoid X receptor (FXR) plays a critical role in the regulation of bile acid, triglyceride (TG), and cholesterol homeostasis. WAY-362450 (FXR-450/XL335) is a potent synthetic FXR agonist as characterized in luciferase reporter assays and in mediating FXR target gene regulation in primary human and immortalized mouse hepatocytes. In vivo, WAY-362450 dose dependently decreased serum TG levels after 7 days of oral dosing in western diet-fed low-density lipoprotein… CONTINUE READING

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