A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in a cannabinoid receptor-independent mechanism in rat cerebellar granule cells.

@article{Chiba2011ASC,
  title={A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in a cannabinoid receptor-independent mechanism in rat cerebellar granule cells.},
  author={Toshiki Chiba and Sanae Ueno and Yutaro Obara and Norimichi Nakahata},
  journal={The Journal of pharmacy and pharmacology},
  year={2011},
  volume={63 5},
  pages={
          636-47
        }
}
OBJECTIVES The inflammatory response plays an important role in the pathogenesis of many diseases in the central nervous system. Cannabinoids exhibit diverse pharmacological actions including anti-inflammatory activity. In this study, we tried to elucidate possible effects of cannabinoids on lipopolysaccharide (LPS)-induced expression of inflammatory cytokine mRNAs in rat cerebellar granule cells. METHODS Inhibitory effects of cannabinoids on cytokine induction in cerebellar granule cells… CONTINUE READING

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Endocannabinoids in cerebrovascular regulation.

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  • 2016
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