A synthetic analog of plantaricin 149 inhibiting food-borne pathogenic bacteria:evidence for alpha-helical conformation involved in bacteria-membrane interaction.

@article{Mller2007ASA,
  title={A synthetic analog of plantaricin 149 inhibiting food-borne pathogenic bacteria:evidence for alpha-helical conformation involved in bacteria-membrane interaction.},
  author={Diana Mar{\'i}a M{\"u}ller and Miguel Angel S{\'a}nchez Carrasco and Arturo Carlos Simonetta and Leila Maria Beltramini and Georgina Guadalupe Tonarelli},
  journal={Journal of peptide science : an official publication of the European Peptide Society},
  year={2007},
  volume={13 3},
  pages={
          171-8
        }
}
Plantaricin-149 is a bacteriocin produced by Lactobacillus plantarum NRIC 149 (a LAB isolated from pineapple), which consists of a peptidic chain made up of 22 amino acid residues [Kato et al. J. Ferment. Bioeng. 1994; 77: 277-282]. In this work, a synthetic C-terminal amidated peptide analog denoted Pln149a was prepared by SPPS-Fmoc chemistry and the antagonistic activity against gram-positive and gram-negative bacteria was tested. The secondary structure was studied by circular dichroism (CD… CONTINUE READING
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