A synthetic TLR3 ligand mitigates profibrotic fibroblast responses by inducing autocrine IFN signaling.

@article{Fang2013AST,
  title={A synthetic TLR3 ligand mitigates profibrotic fibroblast responses by inducing autocrine IFN signaling.},
  author={Feng Fang and Kohtaro Ooka and Xiaoyong Sun and Ruchi Shah and Swati Bhattacharyya and Jun Wei and John Varga},
  journal={Journal of immunology},
  year={2013},
  volume={191 6},
  pages={2956-66}
}
Activation of TLR3 by exogenous microbial ligands or endogenous injury-associated ligands leads to production of type I IFN. Scleroderma patients with progressive skin fibrosis display an IFN-regulated gene signature, implicating TLR3 signaling in the disease. In this study, we show that TLR3 expression was detected on foreskin, adult skin, and lung fibroblasts, and TLR3 levels were significantly elevated in a subset of scleroderma skin biopsies. In explanted skin and lung fibroblasts, the… CONTINUE READING

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