A synthetic, nitrogenated antimetastatic and anti-angiogenic compound with low toxicity in vivo.

@article{Cerutti1999ASN,
  title={A synthetic, nitrogenated antimetastatic and anti-angiogenic compound with low toxicity in vivo.},
  author={Mar{\'i}a Laura Cerutti and E D'Orio and Lilia Elena Davel and Lucas do Amaral Colombo and Pietro Parma and Miriam Diament and Isabel Stillitani and Mar{\'i}a E Gelpi and Silvia Rosa Leicach and Ana Mar{\'i}a Eij{\'a}n},
  journal={International journal of oncology},
  year={1999},
  volume={14 3},
  pages={585-91}
}
The design of more effective therapies for metastatic disease involves development of new compounds able to specifically block the malignant process. We demonstrated previously that a new synthetic nitrogenated compound 3'-1-chloroethyl-2,3-dihydro-1H-imidazo-(2, 1-i)-purine-4-ium-7-yl-3'-deoxy-1',5', 6'-tri-O-(methylsulfonyl)-muco-inositol chloride (DIC) had an anti-proliferative activity on tumor cells in vitro. In the present work we demonstrate that DIC induces apoptosis on the LM3 murine… CONTINUE READING