A synthesis of 7alpha-hydroxyandrost-4-ene-3,17-dione.

  title={A synthesis of 7alpha-hydroxyandrost-4-ene-3,17-dione.},
  author={A B M Bayezid Hossain and D. N. Kirk and Gautam Mitra},
  volume={27 5},
The first convenient chemical synthesis of 7alpha-hydroxyandrost-4-ene-3,17-dione is reported. Androsta-4,6-diene3, 17-dione was converted into its 6alpha, 7alpha-epoxy-derivative; reduction of the epoxide with aluminum amalgam gave 7alpha-hydroxyandrost-4-ene-3,17-dione. This reducing agent is more efficient than chromous acetate for the purpose.