A synthesis of (-)-mintlactone.

Abstract

Mintlactone is synthesized in a concise and efficient way by using a highly diastereoselective intramolecular propargylic Barbier reaction, followed by an allenol cyclocarbonylation. Tin(II) chloride is found to be the most effective reagent for the Barbier reaction. 
DOI: 10.1021/jo801433f

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