A synergistic increase in transplantable peripheral blood stem cells in mice by co-administration of recombinant human interleukin 6 and recombinant human granulocyte colony-stimulating factor.

@article{Suzuki1995ASI,
  title={A synergistic increase in transplantable peripheral blood stem cells in mice by co-administration of recombinant human interleukin 6 and recombinant human granulocyte colony-stimulating factor.},
  author={Hiromi Suzuki and Akira Okano and Chieko Suzuki and Atsushi Konishi and Yoshinobu Akiyama and Toshiyuki Ishibashi and Keiya Ozawa and Shigetaka Asano},
  journal={Transplantation},
  year={1995},
  volume={59 11},
  pages={1596-600}
}
We examined the effects of co-administration of recombinant human (rh) IL-6 (10 micrograms/day) and rh granulocyte colony-stimulating factor (G-CSF) (0.35 micrograms/day) on the number of peripheral blood cells and peripheral progenitor cells in mice. Among blood cells counts, only white blood cells were synergistically enhanced by co-administration of rhIL-6 and rhG-CSF. Moreover, it was found that co-administration of rhIL-6 and rhG-CSF also caused a marked synergistic increase in the number… CONTINUE READING