A synaptic vesicle protein with a novel cytoplasmic domain and four transmembrane regions.

@article{Sdhof1987ASV,
  title={A synaptic vesicle protein with a novel cytoplasmic domain and four transmembrane regions.},
  author={Thomas C S{\"u}dhof and Friedrich Lottspeich and Paul Greengard and Erika Mehl and Reinhard Jahn},
  journal={Science},
  year={1987},
  volume={238 4830},
  pages={1142-4}
}
Complementary DNA and genomic clones were isolated and sequenced corresponding to rat and human synaptophysin (p38), a major integral membrane protein of synaptic vesicles. The deduced amino acid sequences indicate an evolutionarily highly conserved protein that spans the membrane four times. Both amino and carboxyl termini face the cytoplasm, with the latter containing ten copies of a tyrosine-rich pentapeptide repeat. The structure of synaptophysin suggests that the protein may function as a… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 70 extracted citations

Similar Papers

Loading similar papers…