A sychnological cell penetrating peptide mimic of p21(WAF1/CIP1) is pro-apoptogenic.

@article{Baker2007ASC,
  title={A sychnological cell penetrating peptide mimic of p21(WAF1/CIP1) is pro-apoptogenic.},
  author={Rachael D Baker and John D Howl and Iain D. Nicholl},
  journal={Peptides},
  year={2007},
  volume={28 4},
  pages={731-40}
}
Targeting chemotherapeutic agents directly to sites of DNA replication and repair within cancerous cells is problematic. This study attempts to address the issue of nuclear delivery of biologically active peptides with the potential to disrupt cancer cell growth. Herein, the protein transduction domain of the HIV-1 transactivator of transcription, Tat (Tat(48-60)), is used to deliver a cytotoxic peptide mimic of the cyclin-dependent kinase inhibitor, p21(WAF1/CIP1) into the nucleus. This… CONTINUE READING