A switch in the cellular localization of macrophage migration inhibitory factor in the rat testis after ethane dimethane sulfonate treatment.

@article{Meinhardt1999ASI,
  title={A switch in the cellular localization of macrophage migration inhibitory factor in the rat testis after ethane dimethane sulfonate treatment.},
  author={Andreas Meinhardt and Michael Bacher and Moira K O'Bryan and James R. McFarlane and Con Mallidis and Corinna Lehmann and Christine N Metz and David de Kretser and Richard Bucala and Mark P Hedger},
  journal={Journal of cell science},
  year={1999},
  volume={112 ( Pt 9)},
  pages={1337-44}
}
Macrophage migration inhibitory factor (MIF), one of the first cytokines to be discovered, has recently been localized to the Leydig cells in adult rat testes. In the following study, the response of MIF to Leydig cell ablation by the Leydig cell-specific toxin ethane dimethane sulfonate (EDS) was examined in adult male rats. Testicular MIF mRNA and protein in testicular interstitial fluid measured by ELISA and western blot were only marginally reduced by EDS treatment, in spite of the fact… CONTINUE READING