A switch in numb isoforms is a critical step in cortical development.

@article{BaniYaghoub2007ASI,
  title={A switch in numb isoforms is a critical step in cortical development.},
  author={Mahmud Bani-Yaghoub and Chris J. Kubu and Rebecca A. Cowling and Jennifer A. Rochira and George N. Nikopoulos and Stephen C Bellum and Joseph M. Verdi},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2007},
  volume={236 3},
  pages={
          696-705
        }
}
Loss of numb function suggests that numb maintains progenitors in an undifferentiated state. Herein, we demonstrate that numb1 and numb3 are expressed in undifferentiated cortical progenitors, whereas numb2 and numb4 become prominent throughout differentiation. To further assess the role of different numb isoforms in cortical neural development, we first created a Numb-null state with antisense morpholino, followed by the re-expression of specific numb isoforms. The re-expression of numb1 or… CONTINUE READING
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