A switch between topological domains underlies HoxD genes collinearity in mouse limbs.

@article{Andrey2013ASB,
  title={A switch between topological domains underlies HoxD genes collinearity in mouse limbs.},
  author={Guillaume Andrey and Thomas Montavon and B{\'e}n{\'e}dicte Mascrez and Federico Gonzalez and Daan Noordermeer and Marion Leleu and Didier Trono and François Spitz and Denis Duboule},
  journal={Science},
  year={2013},
  volume={340 6137},
  pages={1234167}
}
Hox genes are major determinants of the animal body plan, where they organize structures along both the trunk and appendicular axes. During mouse limb development, Hoxd genes are transcribed in two waves: early on, when the arm and forearm are specified, and later, when digits form. The transition between early and late regulations involves a functional switch between two opposite topological domains. This switch is reflected by a subset of Hoxd genes mapping centrally into the cluster, which… CONTINUE READING
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