A sustained release of lovastatin from biodegradable, elastomeric polyurethane scaffolds for enhanced bone regeneration.

@article{Yoshii2010ASR,
  title={A sustained release of lovastatin from biodegradable, elastomeric polyurethane scaffolds for enhanced bone regeneration.},
  author={Toshitaka Yoshii and Andrea E. Hafeman and Jeffry S Nyman and Javier M Esparza and Kenichi Shinomiya and Dan M. Spengler and Gregory R. Mundy and Gloria E. Gutierrez and Scott A Guelcher},
  journal={Tissue engineering. Part A},
  year={2010},
  volume={16 7},
  pages={2369-79}
}
Scaffolds prepared from biodegradable polyurethanes (PUR) have been investigated as a supportive matrix and delivery system for skin, cardiovascular, and bone tissue engineering. In this study, we combined reactive two-component PUR scaffolds with lovastatin (LV), which has been reported to have a bone anabolic effect especially when delivered locally, for… CONTINUE READING