A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes.

@article{Kashyap2003ASI,
  title={A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes.},
  author={S R Kashyap and Renata Belfort and Amalia Gastaldelli and Thongchai Pratipanawatr and Rachele Berria and Wilailak Pratipanawatr and Mandeep Singh Bajaj and Lawrence J. Mandarino and Ralph A DeFronzo and Kenneth Cusi},
  journal={Diabetes},
  year={2003},
  volume={52 10},
  pages={
          2461-74
        }
}
Acute elevations in free fatty acids (FFAs) stimulate insulin secretion, but prolonged lipid exposure impairs beta-cell function in both in vitro studies and in vivo animal studies. In humans data are limited to short-term (< or =48 h) lipid infusion studies and have led to conflicting results. We examined insulin secretion and action during a 4-day lipid infusion in healthy normal glucose tolerant subjects with (FH+ group, n = 13) and without (control subjects, n = 8) a family history of type… CONTINUE READING

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