A susceptibility allele from a non-diabetes-prone mouse strain accelerates diabetes in NOD congenic mice.

@article{Brodnicki2003ASA,
  title={A susceptibility allele from a non-diabetes-prone mouse strain accelerates diabetes in NOD congenic mice.},
  author={Thomas C Brodnicki and Fiona Quirk and Grant Morahan},
  journal={Diabetes},
  year={2003},
  volume={52 1},
  pages={
          218-22
        }
}
The nonobese diabetic (NOD) mouse is genetically predisposed for the spontaneous development of type 1 diabetes. Linkage analyses have identified at least 19 susceptibility loci (Idd1-Idd19) that contribute to disease pathogenesis in which lymphocytes mediate the specific destruction of insulin-producing beta-cells. Interestingly, nondiabetic mouse strains have been shown to confer susceptibility alleles to affected progeny in NOD outcrosses for some of the Idd loci. In particular, we noted… CONTINUE READING

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