A survey of small RNAs in human sperm.

  title={A survey of small RNAs in human sperm.},
  author={Stephen A. Krawetz and Adele Kruger and Claudia Lalancette and Rebecca Tagett and E. Arrieta Ant{\'o}n and Sorin Draghici and Michael Peter Diamond},
  journal={Human reproduction},
  volume={26 12},
BACKGROUND There has been substantial interest in assessing whether RNAs (mRNAs and sncRNAs, i.e. small non-coding) delivered from mammalian spermatozoa play a functional role in early embryo development. While the cadre of spermatozoal mRNAs has been characterized, comparatively little is known about the distribution or function of the estimated 24,000 sncRNAs within each normal human spermatozoon. METHODS RNAs of <200 bases in length were isolated from the ejaculates from three donors of… CONTINUE READING
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