A survey of carbon fixation pathways through a quantitative lens.

@article{BarEven2012ASO,
  title={A survey of carbon fixation pathways through a quantitative lens.},
  author={Arren Bar‐Even and Elad Noor and Ron Milo},
  journal={Journal of experimental botany},
  year={2012},
  volume={63 6},
  pages={
          2325-42
        }
}
While the reductive pentose phosphate cycle is responsible for the fixation of most of the carbon in the biosphere, it has several natural substitutes. In fact, due to the characterization of three new carbon fixation pathways in the last decade, the diversity of known metabolic solutions for autotrophic growth has doubled. In this review, the different pathways are analysed and compared according to various criteria, trying to connect each of the different metabolic alternatives to suitable… 

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References

SHOWING 1-10 OF 162 REFERENCES
Design and analysis of synthetic carbon fixation pathways
TLDR
This study computationally identified alternative carbon fixation pathways that combine existing metabolic building blocks from various organisms using the entire repertoire of approximately 5,000 metabolic enzymes known to occur in nature, and suggests some of the proposed synthetic pathways could have significant quantitative advantages over their natural counterparts.
Alternative pathways of carbon dioxide fixation: insights into the early evolution of life?
  • G. Fuchs
  • Biology
    Annual review of microbiology
  • 2011
TLDR
Five alternative autotrophic pathways exist in prokaryotes that differ fundamentally from the Calvin-Benson cycle and reveal that the formation of an activated acetic acid from inorganic carbon represents the initial step toward metabolism.
Beyond the Calvin cycle: autotrophic carbon fixation in the ocean.
TLDR
Recent discoveries in the field of autotrophic carbon fixation are reviewed, including the biochemistry and evolution of the different pathways, as well as their ecological relevance in various oceanic ecosystems.
Computation of metabolic fluxes and efficiencies for biological carbon dioxide fixation.
Labeling and Enzyme Studies of the Central Carbon Metabolism in Metallosphaera sedula
TLDR
The picture of the central carbon metabolism in autotrophic Sulfolobales is completed by connecting the autosphaera sedula carbon fixation cycle to the formation of central carbon precursor metabolites.
CO2 fixation in acetogenic bacteria: Variations on a theme
TLDR
Emphasis is placed upon the acetyl CoA pathway in acetogenic bacteria, but important advances in the study of other strict anaerobes are also considered.
Microbial Inorganic Carbon Fixation
TLDR
An introduction to the various mechanisms of carbon dioxide fixation utilised by microorganisms as well as a list of unique carbon dioxide-fixing pathways known at present.
Enzymology of the Wood–Ljungdahl Pathway of Acetogenesis
  • S. Ragsdale
  • Biology
    Annals of the New York Academy of Sciences
  • 2008
The biochemistry of acetogenesis is reviewed. The microbes that catalyze the reactions that are central to acetogenesis are described and the focus is on the enzymology of the process. These microbes
Autotrophic carbon fixation in archaea
TLDR
The diverse carbon fixation mechanisms that are found in archaea differ fundamentally from those of the well-known Calvin cycle, and their distribution mirrors the phylogenetic positions of the archaeal lineages and the needs of the ecological niches that they occupy.
...
1
2
3
4
5
...