A survey of RNA editing in human brain.

  title={A survey of RNA editing in human brain.},
  author={Matthew J. Blow and P. Andrew Futreal and Richard Wooster and Michael R. Stratton},
  journal={Genome research},
  volume={14 12},
We have conducted a survey of RNA editing in human brain by comparing sequences of clones from a human brain cDNA library to the reference human genome sequence and to genomic DNA from the same individual. In the RNA sample from which the library was constructed, approximately 1:2000 nucleotides were edited out of >3 Mb surveyed. All edits were adenosine to inosine (A-->I) and were predominantly in intronic and in intergenic RNAs. No edits were found in translated exons and few in untranslated… CONTINUE READING
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