A surprising cross-species conservation in the genomic landscape of mouse and human oral cancer identifies a transcriptional signature predicting metastatic disease.

@article{Onken2014ASC,
  title={A surprising cross-species conservation in the genomic landscape of mouse and human oral cancer identifies a transcriptional signature predicting metastatic disease.},
  author={Michael D Onken and Ashley E. Winkler and Krishna-Latha Kanchi and Varun Chalivendra and Jonathan H Law and Charles G. Rickert and Dorina Kallogjeri and Nancy P. Judd and Gavin P Dunn and Jay F. Piccirillo and James S Lewis and Elaine R. Mardis and Ravindra Uppaluri},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2014},
  volume={20 11},
  pages={2873-84}
}
PURPOSE Improved understanding of the molecular basis underlying oral squamous cell carcinoma (OSCC) aggressive growth has significant clinical implications. Herein, cross-species genomic comparison of carcinogen-induced murine and human OSCCs with indolent or metastatic growth yielded results with surprising translational relevance. EXPERIMENTAL DESIGN Murine OSCC cell lines were subjected to next-generation sequencing (NGS) to define their mutational landscape, to define novel candidate… CONTINUE READING