A surgical technique for safely placing a drug delivery catheter into the pons of primates: preliminary results of carboplatin infusion.

Abstract

OBJECTIVE We sought to develop a neurosurgical procedure to access the pons with a drug delivery device for chronic therapy and collect preliminary data on the toxicity of direct infusions of carboplatin in primates. METHODS We made midline incisions on five cynomolgus monkeys, identified the inion, made a burr hole 2.5 cm below the inion, and inserted a… (More)

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