A surface-eroding antibiotic delivery system based on poly-(trimethylene carbonate).

@article{Kluin2009ASA,
  title={A surface-eroding antibiotic delivery system based on poly-(trimethylene carbonate).},
  author={Otto S Kluin and Henny C van der Mei and Henk J. Busscher and Dani{\"e}lle Neut},
  journal={Biomaterials},
  year={2009},
  volume={30 27},
  pages={4738-42}
}
Biodegradable delivery systems that do not produce acidic compounds during degradation are preferred for local antibiotic delivery in bone infections in order to avoid adverse bone reactions. Poly(trimethylene carbonate) (PTMC) has good biocompatibility, and is such a polymer. The objective of this in vitro study was to explore the suitability of PTMC as an antibiotic releasing polymer for the local treatment of bone infections. Degradation behaviour and corresponding release profiles of… CONTINUE READING
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Triblock copolymers based on 1,3-trimethylene carbonate and lactide as biodegradable thermoplastic elastomers

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