A suppressor T cell of the mixed lymphocyte reaction specific for the HLA-D region in man.

  title={A suppressor T cell of the mixed lymphocyte reaction specific for the HLA-D region in man.},
  author={Edgar G Engleman and Hugh O Mcdevitt},
  journal={The Journal of clinical investigation},
  volume={61 3},
The mixed lymphocyte reaction (MLR) is the proliferative response of one individual's lymphocytes cultured in the presence of another individual's lymphocytes. In man, the MLR is elicited by cell surface antigens coded for by the HLA-D gene locus. This locus is among a cluster of genes which are located on the sixth chromosome and which include genes coding for the major histocompatibility antigens HLA-A, B, and C as well as HLA-D. If the stimulator cell possesses D locus antigens not present… CONTINUE READING
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