A suppressive role of nitric oxide in MIP-2 production by macrophages upon coculturing with apoptotic cells.

@article{Shibata2006ASR,
  title={A suppressive role of nitric oxide in MIP-2 production by macrophages upon coculturing with apoptotic cells.},
  author={Takehiko Shibata and Kisaburo Nagata and Yoshiro Kobayashi},
  journal={Journal of leukocyte biology},
  year={2006},
  volume={80 4},
  pages={744-52}
}
Macrophages phagocytose apoptotic cells without causing neutrophil infiltration in vivo under physiological conditions. Our recent study, however, showed that macrophages produce IL-8 or MIP-2, a murine IL-8 homologue, upon coculturing with apoptotic cells, indicating that there must be unknown mechanisms for preventing IL-8 or MIP-2 production. As activated macrophages produce NO to regulate inflammation, we examined the NO production by macrophages upon coculturing with apoptotic or necrotic… CONTINUE READING

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