A superoxide anion induced DNA strand-break metabolic pathway in human leukocytes: effects of vanadate.

  • H Chaim Birnboim
  • Published 1988 in
    Biochemistry and cell biology = Biochimie et…


Superoxide anion (O2-) is an active oxygen species found in virtually all cells grown in the presence of oxygen. In vivo, the highest concentration of this oxygen radical is found after granulocytes have been exposed to particles or the tumor promoter, phorbol myristate acetate. O2- is released from the cell as a "respiratory burst," which is followed… (More)