A sulfated polysaccharide, fucans, isolated from brown algae Sargassum vulgare with anticoagulant, antithrombotic, antioxidant and anti-inflammatory effects.

Abstract

Fucan (SV1) sulfated polysaccharides from the brown algae Sargassum vulgare were extracted, fractionated in acetone and examined with respect to chemical composition, anticoagulant, anti-inflammatory, antithrombotic effects and cellular proliferation. These polysaccharides contain low levels of protein, high level of carbohydrate and sulfate. Monosaccharides analysis revealed that SV1 was composed of fucose, galactose, xylose, glucuronic acid and mannose. SV1 polysaccharide prolonged activated partial thromboplastin time (aPTT) and exhibited high antithrombotic action in vivo, with a concentration ten times higher than heparin activity. PSV1, a purified form in gel filtration showed very low biological activities. SV1 stimulated the enzymatic activity of FXa. Its action on DPPH radical scavenging activity was 22%. This polymer has no cytotoxic action (hemolytic) on ABO and Rh blood types in different erythrocyte groups. It displays strong anti-inflammatory action at all concentrations tested in the carrageenan-induced paw edema model, demonstrated by reduced edema and cellular infiltration.

DOI: 10.1016/j.carbpol.2012.07.075
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@article{Dore2013ASP, title={A sulfated polysaccharide, fucans, isolated from brown algae Sargassum vulgare with anticoagulant, antithrombotic, antioxidant and anti-inflammatory effects.}, author={Celina Maria P Guerra Dore and Monique Gabriela das C Faustino Alves and Luiza Sheyla E Pof{\'i}rio Will and Thiago G. Costa and Diego Ara{\'u}jo Sabry and Leonardo Augusto R de Souza R{\^e}go and Camila de Melo Accardo and Hugo Alexandre Oliveira Rocha and Luciana Guimar{\~a}es Alves Filgueira and Edda Lisboa Leite}, journal={Carbohydrate polymers}, year={2013}, volume={91 1}, pages={467-75} }