A suicidal strain of Listeria monocytogenes is effective as a DNA vaccine delivery system for oral administration.

@article{Sinha2017ASS,
  title={A suicidal strain of Listeria monocytogenes is effective as a DNA vaccine delivery system for oral administration.},
  author={Shubhra Sinha and Cheng-Yi Kuo and Joan K. Ho and Paul White and Jalal A. Jazayeri and Colin W. Pouton},
  journal={Vaccine},
  year={2017},
  volume={35 38},
  pages={5115-5122}
}
In this study we determined the in vivo activity of model ovalbumin vaccines delivered by direct intramuscular delivery of plasmid DNA or oral delivery using a recombinant suicidal Listeria monocytogenes strain (rsΔ2). In a previous report we described how rsΔ2 is capable of delivering luciferase, as protein or DNA, in vitro, into non-dividing intestinal epithelial cells (Kuo et al., 2009). This is achieved by engineering a dual expression shuttle vector, pDuLX-Luc, that replicates in E. coli… CONTINUE READING

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