A suggested approach to once-daily aminoglycoside dosing.

  title={A suggested approach to once-daily aminoglycoside dosing.},
  author={Evan James Begg and Murray Lindsay Barclay and Stephen B. Duffull},
  journal={British journal of clinical pharmacology},
  volume={39 6},
1. Once-daily aminoglycoside dosing has many advantages and has been widely advocated. However, existing guidelines for methods of administration and monitoring are non-specific and may lead to excessive dosing. 2. The traditional approach of aiming for target peak and trough concentrations is not appropriate for once-daily dosing. 3. A method is proposed which uses a target area under the concentration-time curve (AUC) for the aminoglycoside based on the 24 h AUC that would result with… CONTINUE READING

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