A successful program of immunizing Rh-negative male volunteers for anti-D production using frozen/thawed blood.

@article{Urbaniak1981ASP,
  title={A successful program of immunizing Rh-negative male volunteers for anti-D production using frozen/thawed blood.},
  author={Stanislaw J. Urbaniak and Amanda Robertson},
  journal={Transfusion},
  year={1981},
  volume={21 1},
  pages={64-9}
}
Individually matched (rhesus-D) Rh-positive frozen/thawed red blood cells were used to immunize 28 Rh-negative male volunteers. The immunizing schedule consisted of a single unit (200 ml) of frozen/thawed red blood cells, followed by six monthly booster doses (0.5 to 1.0 ml) after a rest period of six months. A final response rate of 93 percent (26 of 28) was achieved. All responders had produced anti-D before the second booster injection (mean detection time 4.25 months). Retrospective… CONTINUE READING