A subunit of the anaphase-promoting complex is a centromere-associated protein in mammalian cells.

@article{Jrgensen1998ASO,
  title={A subunit of the anaphase-promoting complex is a centromere-associated protein in mammalian cells.},
  author={Prof. dr. med. G. J{\"o}rgensen and Eva Brundell and Maria Starborg and Christer H{\"o}{\"o}g},
  journal={Molecular and cellular biology},
  year={1998},
  volume={18 1},
  pages={468-76}
}
Sister chromatids in early mitotic cells are held together mainly by interactions between centromeres. The separation of sister chromatids at the transition between the metaphase and the anaphase stages of mitosis depends on the anaphase-promoting complex (APC), a 20S ubiquitin-ligase complex that targets proteins for destruction. A subunit of the APC, called APC-alpha in Xenopus (and whose homologs are APC-1, Cut4, BIME, and Tsg24), has recently been identified and shown to be required for… CONTINUE READING

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Highly Influential
4 Excerpts

LOCALIZATION OF AN APC SUBUNIT TO THE CENTROMERE 475 on D ecem er 21, 2017 by gest hp://m c.asm .rg/ D ow nladed fom Nicoud

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